Ledger Nano S and Ledger Blue both operate with there own cryptocurrency wallet interfaces: "Ledger Apps". This is a free Google Chrome application. You can also use the app; Ledger Wallet Ripple.
The Ledger Wallet Ripple app is a free download that works on Windows, Linux, & Mac OS. It runs seamlessly on your Ledger Nano S or Ledger Blue.
Open Source Software
All Ledger Apps are open source. Anyone can access the full source code, to authenticate or contribute to its development.
The Ledger Wallet Ripple app makes it easy to manage your account. Sending and receiving funds, checking balance, transaction history and more.
Ripple sensitive operations "signatures" are done inside the device. This ensures a secure environment so your assets are never exposed online or on your computer.